From "HISTORY OF THE UPPER OHIO VALLEY," Vol. I, pages 332-335 & 580. Brant & Fuller, 1890. ALFRED HUGHES Alfred Hughes, M. D., of Baltimore, Md., was born at Wheeling, Va., on September 16, 1824. His great-grandfather, Felix Hughes, was a native of Ireland. He was a devout Catholic, and left the land of his birth to find that religious freedom that he was there denied. He came to this country and settled in Loudon county, Va., in 1732. Four sons were born to him, of whom James, the grandfather of our subject, was a great huntsman, and crossing the mountains in quest of game, saw the beautiful region that is now Greene county, Penn., but then a part of Virginia. He determined to settle there and having married a Miss Dunn, of Jefferson county, Va., in 1772 moved to his newly located home, and was among the first white settlers of that section. At his death he owned large tracts of land in Virginia, Kentucky and what is now Indiana; he left three sons and five daughters, his oldest child being then only nineteen years of age. His youngest child but one, Thomas, was born and raised in what is now Greene county, Penn., and in early life married Mary, daughter of Charles von Odenbaugh of Winchester, Va. They shortly afterward moved to Wheeling, Va., where seven sons and three daughters were born to them. He served under Gen. Harrison in the war of 1812. At his death in 1849, he had been treasurer of the city of Wheeling, and member of the city council for thirty-two years; president of the Wheeling Savings institution; president of the Wheeling Fire Insurance company; president of the Wheeling & Belmont Bridge company, and director in the Northwestern bank. His oldest living son was chosen to fill his place in the city council, and held the position to a year previous to his death, in 1870. His seventh child was our subject. He went through a thorough collegiate course of education, studied medicine and graduated at the Homeopathic Medical college of Philadelphia. On November 1, 1849, he married Mary Kirby Adrian, of Wheeling, a descendant of the Sedgwick family of Maryland, who settled in that state in the early part of the seventeenth century. He began the practice of homeopathy at Wheeling in 1851. Of those who had essayed the task of practicing the new school and failed, two practitioners were from Philadelphia and one from Baltimore. Popular prejudice and the bitter opposition of the old school were too much for them, and their defeat rendered victory more difficult for their successor. Dr. Hughes, however, after a hard fight, and many newspaper controversies, conquered, vindicating the advantages of the homeopathic practice. When the cholera made its appearance, in 1854, he labored constantly night and day, being the only homeopathic physician in the city, and meeting with almost unprecedented success in his treatment of the fearful scourge, then in epidemic form, homeopathy was then firmly established, he soon built up a large and lucrative practice, and now Wheeling, in place of one, has several new school practitioners. On the outbreak of the war, and when the first gun was fired at Charleston, his sympathies were enlisted in behalf of the south. When Virginia seceded, he engaged in newspaper political controversies, and became correspondent for the BALTIMORE EXCHANGE. He was arrested for disloyalty in 1861, and was held a prisoner at Camp Chase, near Columbus, Ohio, for nearly eight months, when he was specially exchanged for a brother of Dr. Pancoast of Philadelphia, captured at Bloomery Gap, Va., and a prisoner at Salisbury, N. C. On his way to Richmond with his wife and three children he stayed in Baltimore, reporting to Gen. Schenck, to whom he had letters of introduction. He obtained from the secretary of war, Stanton, a permit to take his wife and children and extra baggage to Richmond. On the steamer in which they sailed for Fortress Monroe were several distinguished federal generals, among them Gen. Thomas, who rendered them great service in getting through their extensive baggage, consisting of some thirteen trunks, at a time when scarcely a bundle was permitted to go by a flag of truce boat. Having been landed at City Point, and the formalities of exchange gone through, he proceeded with his family to Richmond. At Petersburg he was arrested on a general suspicion created by the amount of his baggage, and it was not until dispatches were received from two of his friends in Richmond, Judge Brokenbrough and Hon. Charles W. Russell, vouching for his loyalty to the south, that he and his baggage were permitted to proceed. His arrival in Richmond accompanied by the unusual amount of baggage gave rise to a report that he was a commissioner of peace sent by the United States government clothed with power to end the war. He at once settled down into practice, and again had to fight homeopathy's battle against bitter prejudice and stubborn opposition. Once more he succeeded in establishing the system, and secured an excellent practice. After a while he was elected to the legislature of Virginia, and remained a member thereof up to the fall of Richmond. He was a warm advocate of the enlistment of slaves in the southern ranks. Among his patients during and since the war was the wife of Gen. Robert E. Lee. On December 18, 1865, he removed from Richmond to Baltimore, where he soon established himself in a good and lucrative practice, such a one, indeed, as is obtained by few, even after long residence in a city. This he has done in spite of much competition. Thus he has established in his native city, and won respect for it in his own person, in two others. Dr. Hughes was an occasional contributor to the AMERICAN HOMEOPATHIC OBSERVER. He has had ten children, five sons and three daughters of whom are living. His oldest son a graduate in law of the university of Virginia is a practicing lawyer in Baltimore. His oldest daughter in 1869, was married to W. P. Moncure, M. D., son of Judge R. C. L. Moncure, deceased, formerly president of the supreme court of appeals of Virginia. His second daughter in 1877, was married to Frank A. Bond, formerly adjutant-general of the state of Maryland, and an officer in the confederate states army of northern Virginia. His family are widely extended through Virginia, West Virginia and part of Kentucky. He died in Baltimore, Md., February 25, 1880. There is a sketch of his life in Cleave's Biographical Cyclopaedia of Homeopathic Physicians and Surgeons, and in the Biographical Cyclopaedia of Prominent Men in Maryland and the District of Columbia. His eldest son, Thomas, born August 25, 1850, in Wheeling, was at the close of the war a cadet at the Virginia Military institute at Richmond, Va.; graduated in 1871 at the Baltimore City college, first in a class of nineteen students, completing the prescribed course of four years in two years; and in the spring of the following year graduated in law at the university of Virginia, receiving the degree of B. L. He is a prominent lawyer in large practice in Baltimore; a member of the Bar association of Baltimore City, of the American Bar association, of the Maryland Historical society, past master of Concordia lodge, a member of the Jerusalem chapter and Beauseant commandery of Masons, past grand of Baltimore City lodge, and past chief patriarch of Mt. Araratt encampment of Odd Fellows, and a member of the Calumet, Crescent and Atheneum clubs of Baltimore. In 1875 he married Helen R. Thorburn of Fredricksburg, Va., daughter of Capt. Robert Donaldson Thorburn, formerly of the United States navy. Page 580 Alfred Hughes was born in Wheeling, September 16,1894. His ancestors were Irish Catholics, who settled in Virginia in 1732. His father served under Gen. Harrison in the war of 1812, and afterward filled many positions of trust in Wheeling, serving for thirty years as a member of the city council, and being succeeded by his oldest son. Dr. Hughes was the seventh child. After a collegiate course he studied medicine and graduated at the Homceopathic Medical college of Philadelphia. After his marriage to Miss Adrian, he, in 1851, began the practice of homoeopathy in Wheeling. Two "new school" physicians had failed before him, but Dr. Hughes fought a successful battle, and won an excellent practice. It is claimed that he had unusual success in treating cholera during the epidemic of 1854. At the outbreak of the war his sympathies were enlisted in behalf of the south. He was arrested for disloyalty in 1861, and held as a prisoner at Camp Chase, Ohio, for eight months, when he was exchanged for a brother of Dr. Pancoast, of Philadelphia. He then went to Richmond and settled down in practice, in which he was successful. He was elected a member of the Virginia legislature, and so remained until the fall of Richmond. In December, 1865, he removed to Baltimore, where he soon established himself in a lucrative practice. Dr. Hughes was early in the war a correspondent of the BALTIMORE EXCHANGE, and contributed occasional medical paper to the AMERICAN HOMOEOPATHIC OBSERVER. He died in Baltimore, February 25, 1880, highly respected and esteemed by a large circle of friends. (Linda Fluharty)